Quote: local alignment by name is easier to understand, while global alignment works better for ordered data

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Another fundamental consideration in the design of any … and should be synchronized with each other. Synchronization … make alignment decisions locally or globally [e.g., diff3 and 3DM] … our algorithm employs a simple, local alignment strategy … [Local synchronization is easy to understand, but it does not handle ordered data well.] … if no key is available, we might instead … e.g., by concatenating the name data and using … [for synchronization]   Google-1   Google-2

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