We describe a new approach to compression [of protein sequences] that takes account of the underlying biochemical properties. This gives … its similarity to the current context. … [p. 265] Despite the fact that we have found … techniques [such as PPM and GZIP], the result we have obtained is, … over that achieved by a simple order-0 [Markov] model--even using the domain-specific knowledge that is encoded in mutation … the implication is that protein is incompressible. Its … it, or to the fact that it is … most likely answer.
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